Majid Ali, M.D. Arteries tighten and raise pressure of blood within them in response to injustice. For some people, the injustice comes from outside, for others it arises from within. Adverse Effects of Blood Pressure Drugs 1. Fatigue 2. Erectile dysfunction 3. Light-headedness 4. Increased risk of serious head injuries (40% in the elderly) 5. Increased risk of hip fractures