Impeded Progenitor Progression Model of Parkinson’s Disease

                                                   Majid Ali, M.D.

Surgeon, Pathologist, Integrative Physician

Author, The Principles and Practice of Integrative Medicine (in 12 volumes)

                                         140 West End Avenue, New York, NY 10023


344 Prospect Avenue, Hackensack, N.J 07601 


Impeded Progenitor Progression (IPP Model)

of Parkinson’s Disease

Optimizing Cellular Milieu to Prevent Neuronal Loss and Protect Neural Circuits

Parkinson’s disease (PD) is a progressive chronic degenerative disease without any disease-modifying treatment. It is caused by loss of dopamine neurons and disruptions of neural circuits in substantia in the mid-brain region. The common early symptoms are tremor, rigidity, slow movements and difficulty in walking. More than a third of individuals with the disease suffer from anxiety and depression. The primary motor symptoms are collectively referred to as parkinsonism. The cause of PD is remains unknown. Environmental factors, such as certain pesticides and head trauma have been incriminated in its pathogenesis.


IPP Parkinson’s Disease Model 


A Proposed Unifying Model of Strong Explanatory Power For

Bioenergetic Disruptions That Impede Neuronal Progenitor Stem Cell Progression and  Lead to dopaminergic neuronal loss of which causes Parkinson’s disease,  as Well As for Therapies That Pave the Pathways of Normalizing  Progenitor Progression and Restore dopaminergic brain cell population and prevent motor and other symptoms of Parkinson’s disease. Normal Speech, Sociability, Mood, and Immune Aspects

Majid Ali, M.D; FCAP, FRCS (Eng)

Neuronal Progenitor Progression


Neuronal progenitor progression is essential for repair of injured and replacement of lost brain cell in all neurodevelopmental, neurodegenerative, and neuro-regenerative disorders.  This progression depends on the health and strength of the following three primary bioenergetic systems of the body:

  1. Oxygen Bioenenrgetics

  2. Insulin Bioenergetics

  3. Gut Bioenergetics  

The above three bioenenrgetic systems are presented at length in several posts o this site. They can be accessed by using the simple word GIO


G for Gut

I for insulin

O for Oxygen

For example, use GIO HEALTH as search words.



iniatal se    






Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s