The Grease and Detergent Model of Cellular Injury and Healing
Majid Ali, M.D.
In the late 1990s, I put forth The Grease and Detergent Model. In this image, the cell innards, the cell membrane, and the cement that holds the cells together (the matrix) accumulate “cellular grease” due to insufficient detergents in the body. Cellular grease is composed of cellular waste, molecular debris, rancid fats, sticky sugars, and pulped proteins. The primary detergent in the body is oxygen, with secondary “oxy-detergents,” such as hydrogen peroxide, nitric oxide, hydroxyl radicals, oxygen-activated enzymes, and grease-eating phagocytes
The cellular grease, in scientific terms, is composed of:
. Rancid fats are oxidized and peroxidized lipids,
. Sticky sugars are glycosylated proteins and lipids,
. Pulped proteins are cross-linked peptides (chains of amino acids that make up proteins),
Cellular debris, and
. Cellular waste.
This is a vast subject which I address in several articles in my Insulin Toxicity Series. Here I point out that cellular grease buildup is caused by toxic foods, toxic environment, and toxic thoughts.
I also proposed The Crank-Crank-Shaft Model of Insulin Toxicity to offer a simple and visual model to explain insulin resistance, excess insulin activity (hyperinsulinemia), and insulin toxicity. In simple words, the “crank of insulin” fails to turn the “crank-shaft of insulin receptor” protein embedded in the cell membrane. This happens when the cell membrane is covered with grease—the crank-shaft is rusted, turned, and twisted, so to speak—so rendering insulin ineffective. I point out that the insulin receptor crankshaft is roughly 70 times larger than the insulin crank.
In The Crank-Crank-Shaft Model of Insulin Toxicity, the blood sugar level rises when insulin fails to drive sugar into the cells to be metabolized (“burned”) to produce energy. The pancreas senses the rising blood sugar levels and responds with overproduction of insulin hormone in order to overcome the resistance of cellular grease. This works for sometime. However, excess insulin is fattening, inflaming, and grease-building. So begins the vicious cycle of:
. More grease,
. More insulin resistance,
. Higher blood sugar,
. More insulin production,
. Yet more grease,
. Yet higher blood glucose level,
. Yet more insulin production, and
. Yet more grease.
Medical textbooks state that the cause of insulin resistance is unknown and the only way to lower the raised blood sugar level is to use drugs, all of which work for limited periods of time but deepen the long-term problems of excess insulin and insulin toxicity.
Clinical Significance of The Grease and Detrergent Model of Cellular Injury
The crucial clinical significance of my Crank-Crank-Shaft Model is this: it compels people and their doctors to focus on the real cause of insulin toxicity, the trio of toxicities of foods, environment, and thoughts.